Thursday, May 24, 2012

The legacy of Vidal Sassoon (Powerlineblog)

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Wednesday, May 23, 2012

For Yankees, it seems a lot like 2008

NEW YORK (AP) ? Joe Girardi was frustrated. Six losses in seven games left the New York Yankees last in the AL East.

"I'm hoping this is rock-bottom," the manager said.

No, that's not this week. That was on May 20, 2008, 45 games into Girardi's first season as the Yankees manager ? and the only season since 1994 that New York failed to make the playoffs.

As Yogi Berra says, it gets late early ? especially in the Bronx. For a team that likes to constantly refer to its history, 2012 is starting to resemble 2008, when the Yankees started 20-25 and never really contended. They improved to 22-21 this season by beating Kansas City 3-2 Tuesday night, moving out of a last-place tie with Boston in the AL East.

"I think we're a much better team than what we've played, but it's no fun being down there," Girardi said before the game.

New York's offensive struggles with men on base reached new lows during Monday night's 6-0 loss to the Kansas City Royals. The Yankees went 0 for 13 with runners in scoring position, their most hitless at-bats with RISP since July 1990.

Bases loaded, no outs and they still couldn't score. Robinson Cano looked at strike three, Alex Rodriguez swung at strike three and Raul Ibanez flied out deep.

Even when they hit the ball hard, it's right at someone, prompting captain Derek Jeter to say: "At times, it looks like there's 20 people out there playing defense."

"Everything bad that could be happening right now is happening," Nick Swisher said. "We've just got to start winning."

Several teams are doing that lately at the Yankees' expense. In the last seven days, four different clubs have beaten them, with Kansas City joining Cincinnati, Toronto and Baltimore. It's the second time this year that four teams have defeated the Yankees in a single week, STATS LLC.

A 5?-game deficit in the AL East could be wiped out rather quickly, but the Yankees seem to be adrift.

"I haven't sensed a panic from our players. I think our players have remained positive," Girardi said. "Panic's not going to help anyone. It's just going to tighten players up and it's not really going to help. The concern that you could get sometimes is players trying to do too much, and I think that's what you really have to guard against with this group."

A handful of key pieces are missing.

Left fielder Brett Gardner has been sidelined by an elbow injury since April 17, sapping the batting order of spark and speed. Star closer Mariano Rivera is likely out for the season after tearing a ligament in his right knee while shagging fly balls at Kansas City on May 3. His replacement, David Robertson, is on the disabled list with a strained muscle in his left ribcage.

Before Rivera got hurt, the Yankees were batting .270 with runners in scoring position. Now, they have eight hits in their last 79 at-bats (.101) with runners in scoring position over the past 10 games. New York is 0-10 when failing to hit a home run.

"It's very frustrating," Rodriguez said. "We've talked about it over and over again. You can't really describe it. It's not a lot of fun obviously going out and not getting the job done. But at this point, nobody's going to feel sorry for us."

CC Sabathia (5-2, 3.78 ERA) and Ivan Nova (4-2, 5.69) have winning records, but Hideki Kuroda (3-6, 4.56) and Phil Hughes (4-5, 4.94) have lagged. Freddy Garcia (0-2, 8.22) was sent to the bullpen, eventually clearing a spot for Andy Pettitte (1-1, 2.51).

At .265 going into Tuesday, the batting average was among the AL's highest ? though not up to the Yankees' standards.

And the fans are letting them know, with the boos getting louder.

"You're going to hear it on the road, and you're going to hear it at home when you don't play well," Girardi said. "It's because our fans are passionate and they want us to win. And I understand that. So do the guys in that room. If they're unhappy with us, believe me, we're probably unhappier."

Girardi was asked Tuesday if he had heard from ownership lately. He said he had received some text messages, "but nothing out of the ordinary."

"I'm not a guy that's going to go turn over a table. I'm not a guy that's going to jump on a table when we win either, and do a dance. That's not who I am. I've found that managers who have that pretty constant personality are the ones that get the most out of their players," Girardi said. "These are the guys that have to get it done for us. These are our guys ? that we're committed to, that we believe in, that we've seen do it year after year after year."

In the quiet clubhouse late Monday night, several players attributed the lack of offense at times ? and the losing ? to bad luck.

"More than anything, we've just got to pull together. We've got to have faith in each other. We know that we're all capable of doing the job. The back of everybody's baseball card looks pretty good," Swisher said. "Obviously the start hasn't been good for a lot of us ? it's been good for some of us. But we've just got to keep pushing, man, because this team is a never-give-up type of team. And regardless of where we are right now, we're going to keep fighting, man, I can promise you that."

Cano, Rodriguez and Swisher were among the hitters out early taking extra batting practice or doing early side work Tuesday. Hitting coach Kevin Long said the Yankees' record is "not acceptable," but the team is trying to stay as loose as possible and have some fun.

"It's tough. There's not too many people in a good mood, including myself," he said. "It's not for lack of effort. It's not for not paying attention to what we're doing. It's just one of those stretches where you scratch your head and you throw your arms up."

At 31 years, 222 days, the Yankees easily started the season with the oldest average roster, according to STATS. The Royals ? the youngest at 27 years, 155 days, seemed to have a lot more energy.

While acknowledging "the scoreboard definitely speaks for itself," center fielder Curtis Granderson said the Yankees just have to persevere during their slump and remain in position to make a run.

"You know you're going to have some ups and downs," he said. "Right now, as a whole, we're pretty much having a down. And that's probably the most interesting thing, the fact that there's so many guys that just haven't gotten it going yet. But that's baseball. That means the good side is when we do all finally get it going together, we're going to be very tough.

"And there's still a long time for everything to go ahead and get on the same page. So it just takes a couple things here and there, a couple balls to fall, a couple balls to go our way," he said.

___

AP Sports Writer Mike Fitzpatrick contributed to this report.

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Tuesday, May 22, 2012

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You should feel a bit more confident about using credit cards now that you have finished this article. If you are still unsure, then reread it, and continue to search for other information about responsible credit from other sources. After teaching yourself these things, credit can become a trusted friend.

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Better tests for sleeping sickness

Better tests for sleeping sickness [ Back to EurekAlert! ] Public release date: 22-May-2012
[ | E-mail | Share Share ]

Contact: Lies Van Nieuwenhove
lvnieuwenhove@itg.be
32-496-274-434
Institute of Tropical Medicine Antwerp

Lies Van Nieuwenhove, researcher at the Antwerp Institute of Tropical Medicine, has produced proteins imitating typical parts of the sleeping sickness parasite. They can be used in more efficient diagnostic tests, without the need for culturing dangerous parasites.

Each year many thousands of Africans contract sleeping sickness. The cause is a unicellular parasite, a trypanosome, which is transmitted by the bite of tsetse flies. First the parasite multiplies in blood and lymph, while evading the human immune system. It then lodges in organs like heart and kidneys and finally in the brain. Patients become disoriented, their sleeping pattern disintegrates and they get motor and mental problems. This inevitably leads to coma and death. The World Health Organisation estimates that sleeping sickness each year claims 10 000 to 20 000 lives.

In an early stage the disease is easy to treat, but once the brain is invaded, the treatment becomes more complex and one must use medicines with dangerous, even deadly, side effects. So it is important to detect the infection early.

In the regions where Trypanosoma brucei gambiense is found, medical workers for decades already use a rapid diagnostic test, developed at the Institute of Tropical Medicine, to screen millions of people each year on the presence of antibodies in their blood.

But diagnostic test are not perfect: they always will miss cases, or on the contrary they see an infection where there isn't. A bit as the metal detectors at airports: too sensitive and they annoyingly go off on each buckle, earring or coin; a bit less sensitive and pocketknives start slipping trough.

In recent years the number of cases has come down substantially, thanks to campaigns against the disease, so error margins that were acceptable in the old days, because the tests still saved so many lives, now become inadmissible. Research scientist Lies Van Nieuwenhove set out to develop a new and better test.

In such tests one demonstrates the antibodies by presenting them targets they will also recognise and attack on real trypanosomes: typical proteins that cover the parasite as a mantle. When antibody and target react when the test is 'positive' this is made visible by for instance a colour change or a clotting. Today those targets are obtained from living parasites that are raised in laboratory animals, and are a constant danger for the laboratory technicians.

Therefore Van Nieuwenhove tried to synthesise artificial targets, 'mimotopes' that mimic only a part of the original target protein, but still are sufficient to react with the patient's antibodies. She indeed could produce mimotopes that are reliable and give alarm with the right patients. These mimotopes now can be the base for a new generation of rapid diagnostic tests for sleeping sickness.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Better tests for sleeping sickness [ Back to EurekAlert! ] Public release date: 22-May-2012
[ | E-mail | Share Share ]

Contact: Lies Van Nieuwenhove
lvnieuwenhove@itg.be
32-496-274-434
Institute of Tropical Medicine Antwerp

Lies Van Nieuwenhove, researcher at the Antwerp Institute of Tropical Medicine, has produced proteins imitating typical parts of the sleeping sickness parasite. They can be used in more efficient diagnostic tests, without the need for culturing dangerous parasites.

Each year many thousands of Africans contract sleeping sickness. The cause is a unicellular parasite, a trypanosome, which is transmitted by the bite of tsetse flies. First the parasite multiplies in blood and lymph, while evading the human immune system. It then lodges in organs like heart and kidneys and finally in the brain. Patients become disoriented, their sleeping pattern disintegrates and they get motor and mental problems. This inevitably leads to coma and death. The World Health Organisation estimates that sleeping sickness each year claims 10 000 to 20 000 lives.

In an early stage the disease is easy to treat, but once the brain is invaded, the treatment becomes more complex and one must use medicines with dangerous, even deadly, side effects. So it is important to detect the infection early.

In the regions where Trypanosoma brucei gambiense is found, medical workers for decades already use a rapid diagnostic test, developed at the Institute of Tropical Medicine, to screen millions of people each year on the presence of antibodies in their blood.

But diagnostic test are not perfect: they always will miss cases, or on the contrary they see an infection where there isn't. A bit as the metal detectors at airports: too sensitive and they annoyingly go off on each buckle, earring or coin; a bit less sensitive and pocketknives start slipping trough.

In recent years the number of cases has come down substantially, thanks to campaigns against the disease, so error margins that were acceptable in the old days, because the tests still saved so many lives, now become inadmissible. Research scientist Lies Van Nieuwenhove set out to develop a new and better test.

In such tests one demonstrates the antibodies by presenting them targets they will also recognise and attack on real trypanosomes: typical proteins that cover the parasite as a mantle. When antibody and target react when the test is 'positive' this is made visible by for instance a colour change or a clotting. Today those targets are obtained from living parasites that are raised in laboratory animals, and are a constant danger for the laboratory technicians.

Therefore Van Nieuwenhove tried to synthesise artificial targets, 'mimotopes' that mimic only a part of the original target protein, but still are sufficient to react with the patient's antibodies. She indeed could produce mimotopes that are reliable and give alarm with the right patients. These mimotopes now can be the base for a new generation of rapid diagnostic tests for sleeping sickness.

###



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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